60S ribosomal protein L27a

Protein found in humans
RPL27A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4BXF, 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC

Identifiers
AliasesRPL27A, L27A, ribosomal protein L27a
External IDsOMIM: 603637; MGI: 1347076; HomoloGene: 115477; GeneCards: RPL27A; OMA:RPL27A - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RPL27A
Genomic location for RPL27A
Band11p15.4Start8,682,788 bp[1]
End8,714,759 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for RPL27A
Genomic location for RPL27A
Band7 E3|7 57.26 cMStart109,118,354 bp[2]
End109,121,574 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • bone marrow cells

  • anterior pituitary

  • left lobe of thyroid gland

  • mucosa of transverse colon

  • left ovary

  • right lobe of thyroid gland

  • olfactory zone of nasal mucosa

  • right uterine tube

  • stromal cell of endometrium
Top expressed in
  • epiblast

  • uterus

  • thymus

  • embryo

  • embryo

  • yolk sac

  • lens

  • ventricular zone

  • esophagus

  • spleen
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • structural constituent of ribosome
  • RNA binding
Cellular component
  • intracellular anatomical structure
  • ribosome
  • large ribosomal subunit
  • membrane
  • cytosolic large ribosomal subunit
  • endoplasmic reticulum
  • cytosol
Biological process
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • SRP-dependent cotranslational protein targeting to membrane
  • viral transcription
  • translational initiation
  • protein biosynthesis
  • rRNA processing
  • cytoplasmic translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6157

26451

Ensembl

ENSG00000166441

ENSMUSG00000046364

UniProt

P46776

P14115

RefSeq (mRNA)

NM_032650
NM_000990

NM_011975

RefSeq (protein)

NP_000981

NP_036105

Location (UCSC)Chr 11: 8.68 – 8.71 MbChr 7: 109.12 – 109.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L27a is a protein that in humans is encoded by the RPL27A gene.[5][6][7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166441 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046364 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b "Entrez Gene: RPL27A ribosomal protein L27a".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–947. doi:10.1139/o95-101. PMID 8722009.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues" (PDF). Bioinformatics. 17 (12): 1152–1157. doi:10.1093/bioinformatics/17.12.1152. PMID 11751223.
  • Kusuda J, Hirai M, Tanuma R, et al. (1999). "Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A". Cytogenet. Cell Genet. 85 (3–4): 248–251. doi:10.1159/000015303. PMID 10449908. S2CID 7314458.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts