ASCC3

Protein-coding gene in the species Homo sapiens
ASCC3
Identifiers
AliasesASCC3, ASC1p200, HELIC1, RNAH, activating signal cointegrator 1 complex subunit 3
External IDsOMIM: 614217; MGI: 1925237; HomoloGene: 4973; GeneCards: ASCC3; OMA:ASCC3 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ASCC3
Genomic location for ASCC3
Band6q16.3Start100,508,194 bp[1]
End100,881,372 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for ASCC3
Genomic location for ASCC3
Band10|10 B3Start50,468,765 bp[2]
End50,727,581 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • decidua

  • secondary oocyte

  • Achilles tendon

  • gonad

  • stromal cell of endometrium

  • ventricular zone

  • testicle

  • islet of Langerhans

  • bone marrow cells

  • right coronary artery
Top expressed in
  • spermatid

  • tail of embryo

  • gastrula

  • spermatocyte

  • genital tubercle

  • epithelium of small intestine

  • supraoptic nucleus

  • hand

  • ascending aorta

  • submandibular gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • 3'-5' DNA helicase activity
  • protein binding
  • hydrolase activity
  • ATP binding
  • helicase activity
  • nucleic acid binding
  • RNA binding
Cellular component
  • intracellular anatomical structure
  • membrane
  • nucleoplasm
  • nucleus
  • cytosol
  • activating signal cointegrator 1 complex
  • nuclear speck
  • cytoplasm
  • Golgi apparatus
Biological process
  • DNA dealkylation involved in DNA repair
  • DNA duplex unwinding
  • cell population proliferation
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • cellular response to DNA damage stimulus
  • DNA repair
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10973

77987

Ensembl

ENSG00000112249

ENSMUSG00000038774

UniProt

Q8N3C0

E9PZJ8

RefSeq (mRNA)

NM_001284271
NM_006828
NM_022091

NM_198007

RefSeq (protein)

NP_001271200
NP_006819
NP_071374

NP_932124

Location (UCSC)Chr 6: 100.51 – 100.88 MbChr 10: 50.47 – 50.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.[5][6]

Interactions

ASCC3 has been shown to interact with RELA,[7] C-jun[7] and Serum response factor.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112249 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038774 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Coulie PG, Ikeda H, Baurain JF, Chiari R (Jun 1999). "Antitumor immunity at work in a melanoma patient". Advances in Cancer Research. 76: 213–42. doi:10.1016/S0065-230X(08)60778-2. ISBN 978-0-12-006676-6. PMID 10218103.
  6. ^ "Entrez Gene: ASCC3 activating signal cointegrator 1 complex subunit 3".
  7. ^ a b c Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.

External links

Further reading

  • Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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