BEGAIN

Protein-coding gene in the species Homo sapiens
BEGAIN
Identifiers
AliasesBEGAIN, brain enriched guanylate kinase associated
External IDsMGI: 3044626; HomoloGene: 10829; GeneCards: BEGAIN; OMA:BEGAIN - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for BEGAIN
Genomic location for BEGAIN
Band14q32.2Start100,537,147 bp[1]
End100,587,413 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for BEGAIN
Genomic location for BEGAIN
Band12|12 F1Start108,998,113 bp[2]
End109,034,143 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • anterior cingulate cortex

  • body of pancreas

  • Brodmann area 9

  • amygdala

  • anterior pituitary

  • hippocampus proper

  • nucleus accumbens

  • orbitofrontal cortex
Top expressed in
  • hypothalamus

  • striatum of neuraxis

  • superior frontal gyrus

  • primary visual cortex

  • hippocampus proper

  • olfactory bulb

  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell

  • layer of retina

  • neural layer of retina
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57596

380785

Ensembl

ENSG00000183092

ENSMUSG00000040867

UniProt

Q9BUH8

Q68EF6

RefSeq (mRNA)

NM_001159531
NM_020836

NM_001163175
NM_001374200
NM_001374201
NM_001374202
NM_001374203

RefSeq (protein)

NP_001153003
NP_065887

NP_001156647

Location (UCSC)Chr 14: 100.54 – 100.59 MbChr 12: 109 – 109.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Brain-enriched guanylate kinase-associated protein is an enzyme that in humans is encoded by the BEGAIN gene.[5][6]

Interactions

BEGAIN has been shown to interact with Retinoblastoma-like protein 1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183092 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040867 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (September 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. ^ "Entrez Gene: KIAA1446 likely ortholog of rat brain-enriched guanylate kinase-associated protein".
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

Further reading

  • Deguchi M, Hata Y, Takeuchi M, Ide N, Hirao K, Yao I, Irie M, Toyoda A, Takai Y (1998). "BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein". J. Biol. Chem. 273 (41): 26269–72. doi:10.1074/jbc.273.41.26269. PMID 9756850.
  • Yao I, Iida J, Nishimura W, Hata Y (2002). "Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein". J. Neurosci. 22 (13): 5354–64. doi:10.1523/JNEUROSCI.22-13-05354.2002. PMC 6758191. PMID 12097487.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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