DDX10

Protein-coding gene in the species Homo sapiens

DDX10

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2PL3

Identifiers

Aliases

DDX10, HRH-J8, DEAD-box helicase 10, Dbp4

External IDs

OMIM: 601235; MGI: 1924841; HomoloGene: 20922; GeneCards: DDX10; OMA:DDX10 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q22.3	Start	108,665,058 bp^[1]
Band	11q22.3	End	108,940,999 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A5.3	Start	53,009,935 bp^[2]
Band	9\|9 A5.3	End	53,159,353 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

testicle

Achilles tendon

right testis

left testis

gonad

ganglionic eminence

ventricular zone

kidney tubule

left uterine tube

Top expressed in

tail of embryo

otic placode

saccule

genital tubercle

Gonadal ridge

epiblast

primitive streak

otic vesicle

hair follicle

maxillary prominence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	RNA helicase activity nucleotide binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding
Cellular component	nucleolus cytoplasm
Biological process	RNA secondary structure unwinding anterior head development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1662


77591

Ensembl


ENSG00000178105


ENSMUSG00000053289

UniProt


Q13206


Q80Y44

RefSeq (mRNA)


NM_004398


NM_029936

RefSeq (protein)


NP_004389


NP_084212

Location (UCSC)

Chr 11: 108.67 – 108.94 Mb

Chr 9: 53.01 – 53.16 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.^[5]^[6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178105 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053289 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Genomics. 33 (2): 199–206. doi:10.1006/geno.1996.0184. PMID 8660968.
^ ^a ^b "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang SC, Lien HC, Xia W, et al. (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2". Cancer Cell. 6 (3): 251–61. doi:10.1016/j.ccr.2004.07.012. PMID 15380516.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Nakao K, Nishino M, Takeuchi K, et al. (2000). "Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome". Intern. Med. 39 (5): 412–5. doi:10.2169/internalmedicine.39.412. PMID 10830185.
Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID 10655059. S2CID 21887748.
Ikeda T, Ikeda K, Sasaki K, et al. (1999). "The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts". Int. J. Hematol. 69 (3): 160–4. PMID 10222653.
Liang WQ, Clark JA, Fournier MJ (1997). "The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein". Mol. Cell. Biol. 17 (7): 4124–32. doi:10.1128/mcb.17.7.4124. PMC 232266. PMID 9199348.
Arai Y, Hosoda F, Kobayashi H, et al. (1997). "The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10". Blood. 89 (11): 3936–44. doi:10.1182/blood.V89.11.3936. PMID 9166830.