DNASE1L2

Protein-coding gene in the species Homo sapiens
DNASE1L2
Identifiers
AliasesDNASE1L2, DNAS1L2, deoxyribonuclease I-like 2, deoxyribonuclease 1 like 2
External IDsOMIM: 602622; MGI: 1913955; HomoloGene: 74391; GeneCards: DNASE1L2; OMA:DNASE1L2 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for DNASE1L2
Genomic location for DNASE1L2
Band16p13.3Start2,235,816 bp[1]
End2,238,711 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for DNASE1L2
Genomic location for DNASE1L2
Band17|17 A3.3Start24,659,055 bp[2]
End24,662,079 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • skin of arm

  • right hemisphere of cerebellum

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • right frontal lobe

  • skin of thigh

  • vulva

  • Brodmann area 9
Top expressed in
  • lip

  • esophagus

  • transitional epithelium of urinary bladder

  • skin of back

  • skin of external ear

  • belly cord

  • neural layer of retina

  • hair follicle

  • granulocyte

  • skin of abdomen
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • calcium ion binding
  • endonuclease activity
  • nuclease activity
  • hydrolase activity
  • deoxyribonuclease activity
  • metal ion binding
  • deoxyribonuclease I activity
Cellular component
  • cytoplasm
  • extracellular region
  • nucleus
Biological process
  • hair follicle development
  • DNA metabolic process
  • DNA catabolic process
  • corneocyte development
  • nucleic acid phosphodiester bond hydrolysis
  • DNA catabolic process, endonucleolytic
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1775

66705

Ensembl

ENSG00000167968

ENSMUSG00000024136

UniProt

Q92874

Q9D1G0

RefSeq (mRNA)

NM_001301680
NM_001374

NM_025718

RefSeq (protein)

NP_001288609
NP_001365

NP_079994

Location (UCSC)Chr 16: 2.24 – 2.24 MbChr 17: 24.66 – 24.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Deoxyribonuclease-1-like 2 is an enzyme that in humans is encoded by the DNASE1L2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167968 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024136 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
  6. ^ Germino GG, Weinstat-Saslow D, Himmelbauer H, Gillespie GA, Somlo S, Wirth B, Barton N, Harris KL, Frischauf AM, Reeders ST (Jun 1992). "The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region". Genomics. 13 (1): 144–51. doi:10.1016/0888-7543(92)90214-D. PMID 1577479.
  7. ^ "Entrez Gene: DNASE1L2 deoxyribonuclease I-like 2".

Further reading

  • Jäger K, Fischer H, Tschachler E, Eckhart L (2008). "Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression". Differentiation. 75 (10): 939–46. doi:10.1111/j.1432-0436.2007.00183.x. PMID 17490414.
  • Fischer H, Eckhart L, Mildner M, et al. (2007). "DNase1L2 degrades nuclear DNA during corneocyte formation". J. Invest. Dermatol. 127 (1): 24–30. doi:10.1038/sj.jid.5700503. PMID 16902420.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Shiokawa D, Matsushita T, Kobayashi T, et al. (2005). "Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines". Genomics. 84 (1): 95–105. doi:10.1016/j.ygeno.2004.02.003. PMID 15203207.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shiokawa D, Tanuma S (2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry. 40 (1): 143–52. doi:10.1021/bi001041a. PMID 11141064.