DYNLT1

Protein-coding gene in the species Homo sapiens
DYNLT1
Identifiers
AliasesDYNLT1, CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1
External IDsOMIM: 601554; MGI: 98643; HomoloGene: 4754; GeneCards: DYNLT1; OMA:DYNLT1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for DYNLT1
Genomic location for DYNLT1
Band6q25.3Start158,636,474 bp[1]
End158,644,743 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for DYNLT1
Genomic location for DYNLT1
Band17 A1|17 3.97 cMStart6,697,511 bp[2]
End6,703,695 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • epithelium of nasopharynx

  • olfactory zone of nasal mucosa

  • palpebral conjunctiva

  • nasal epithelium

  • oral cavity

  • ganglionic eminence

  • islet of Langerhans

  • jejunal mucosa

  • mucosa of paranasal sinus
Top expressed in
  • spermatid

  • spermatocyte

  • neural tube

  • mesencephalon

  • lens

  • testicle

  • islet of Langerhans

  • granulocyte

  • epiblast

  • urinary bladder
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
  • cytoskeletal motor activity
  • protein C-terminus binding
Cellular component
  • cytoplasm
  • Golgi apparatus
  • secretory vesicle
  • spindle
  • dynein complex
  • cytoplasmic microtubule
  • microtubule
  • cytoskeleton
  • host cell
  • extracellular region
  • cytoplasmic dynein complex
  • secretory granule lumen
  • ficolin-1-rich granule lumen
  • mitochondrion
  • lamellipodium
  • neuronal cell body
  • axonal growth cone
Biological process
  • intracellular transport of viral protein in host cell
  • regulation of G protein-coupled receptor signaling pathway
  • negative regulation of neurogenesis
  • nervous system development
  • cell division
  • establishment of mitotic spindle orientation
  • microtubule-dependent intracellular transport of viral material towards nucleus
  • viral entry into host cell
  • cell cycle
  • viral process
  • transport of viral material towards nucleus
  • neutrophil degranulation
  • positive regulation of neuron projection development
  • dendrite development
  • positive regulation of Rac protein signal transduction
  • negative regulation of mitochondrial membrane permeability
  • regulation of GTPase activity
  • neuron projection morphogenesis
  • regulation of cytoskeleton organization
  • negative regulation of cell death
  • axon development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6993

21648

Ensembl

ENSG00000146425

ENSMUSG00000096255

UniProt

P63172

P51807

RefSeq (mRNA)

NM_006519
NM_001291602
NM_001291603

NM_009342

RefSeq (protein)

NP_001278531
NP_001278532
NP_006510

NP_001160099
NP_001186877
NP_001160102
NP_001160101
NP_033368

Location (UCSC)Chr 6: 158.64 – 158.64 MbChr 17: 6.7 – 6.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.[5][6][7]

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146425 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096255 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (Jul 1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet Cell Genet. 73 (1–2): 153–6. doi:10.1159/000134329. PMID 8646886.
  6. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  7. ^ a b "Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1".

Further reading

  • Tete R, de Montgolfier R, Piante M (1971). "[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]". Journal de Médecine de Lyon. 52 (192): 1523–6 passim. PMID 5503857.
  • King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein". J. Biol. Chem. 271 (50): 32281–7. doi:10.1074/jbc.271.50.32281. PMID 8943288.
  • Nagano F, Orita S, Sasaki T, et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.
  • Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. doi:10.1074/jbc.275.4.2399. PMID 10644691.
  • Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937.
  • Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301. S2CID 11632830.
  • Nadano D, Nakayama J, Matsuzawa S, et al. (2002). "Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton". Biochem. J. 364 (Pt 3): 669–77. doi:10.1042/BJ20011836. PMC 1222615. PMID 12049630.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension". Hum. Mol. Genet. 12 (24): 3277–86. doi:10.1093/hmg/ddg365. PMID 14583445.
  • Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
  • Ohka S, Matsuda N, Tohyama K, et al. (2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome". J. Virol. 78 (13): 7186–98. doi:10.1128/JVI.78.13.7186-7198.2004. PMC 421661. PMID 15194795.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • de Wit NJ, Verschuure P, Kappé G, et al. (2005). "Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1". Eur. J. Cell Biol. 83 (7): 337–45. doi:10.1078/0171-9335-00396. PMID 15503857.
  • Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMC 3857739. PMID 15992542.
  • Yeh TY, Peretti D, Chuang JZ, et al. (2007). "Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin". Traffic. 7 (11): 1495–502. doi:10.1111/j.1600-0854.2006.00482.x. PMC 3873093. PMID 16956385.


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