FAM132A

Protein-coding gene in the species Homo sapiens
C1QTNF12
Identifiers
AliasesC1QTNF12, C1QDC2, CTRP12, FAM132A, family with sequence similarity 132 member A, C1q and TNF related 12
External IDsOMIM: 616593; MGI: 1914639; HomoloGene: 12123; GeneCards: C1QTNF12; OMA:C1QTNF12 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for C1QTNF12
Genomic location for C1QTNF12
Band1p36.33Start1,242,446 bp[1]
End1,246,722 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for C1QTNF12
Genomic location for C1QTNF12
Band4 E2|4 87.66 cMStart156,046,775 bp[2]
End156,051,086 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • mucosa of ileum

  • jejunal mucosa

  • duodenum

  • testicle

  • gonad

  • skin of abdomen

  • gastric mucosa

  • skin of limb

  • skin of leg
Top expressed in
  • medullary collecting duct

  • renal corpuscle

  • Epithelium of choroid plexus

  • efferent ductule

  • condyle

  • fossa

  • retinal pigment epithelium

  • Paneth cell

  • brown adipose tissue

  • external carotid artery
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • hormone activity
Cellular component
  • extracellular region
  • extracellular space
Biological process
  • positive regulation of glucose import
  • negative regulation of gluconeogenesis
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus
  • positive regulation of insulin receptor signaling pathway
  • positive regulation of protein kinase B signaling
  • regulation of glucose metabolic process
  • negative regulation of inflammatory response
  • regulation of glucose import
  • regulation of signaling receptor activity
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

388581

67389

Ensembl

ENSG00000184163

ENSMUSG00000023571

UniProt

Q5T7M4

Q8R2Z0

RefSeq (mRNA)

NM_001014980

NM_026125

RefSeq (protein)

NP_001014980

NP_080401

Location (UCSC)Chr 1: 1.24 – 1.25 MbChr 4: 156.05 – 156.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Family with sequence similarity 132, member A also known as adipolin is a protein that in humans is encoded by the FAM132A gene.[5] Adipolin is an adipokine.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184163 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023571 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Family with sequence similarity 132, member A".

Further reading

  • Wei Z, Lei X, Seldin MM, Wong GW (October 2012). "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J. Biol. Chem. 287 (43): 35804–14. doi:10.1074/jbc.M112.365965. PMC 3476250. PMID 22942287.
  • Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N (October 2011). "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552–8. doi:10.1074/jbc.M111.277319. PMC 3186379. PMID 21849507.
  • Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O (January 2013). "Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140–2. doi:10.1136/annrheumdis-2012-201693. PMID 22736092. S2CID 20772682.


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