Frizzled-7

Protein-coding gene in the species Homo sapiens
FZD7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4Z33

Identifiers
AliasesFZD7, FzE3, frizzled class receptor 7
External IDsOMIM: 603410; MGI: 108570; HomoloGene: 20751; GeneCards: FZD7; OMA:FZD7 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for FZD7
Genomic location for FZD7
Band2q33.1Start202,033,855 bp[1]
End202,038,441 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for FZD7
Genomic location for FZD7
Band1 C2|1 30.08 cMStart59,521,583 bp[2]
End59,526,114 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hair follicle

  • germinal epithelium

  • urethra

  • lactiferous duct

  • tibia

  • parotid gland

  • cerebellar vermis

  • parietal pleura

  • cardiac muscle tissue of right atrium

  • seminal vesicula
Top expressed in
  • vestibular membrane of cochlear duct

  • medullary collecting duct

  • renal corpuscle

  • ascending aorta

  • vestibular sensory epithelium

  • Epithelium of choroid plexus

  • aortic valve

  • saccule

  • triceps brachii muscle

  • masseter muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • PDZ domain binding
  • frizzled binding
  • signal transducer activity
  • Wnt-protein binding
  • protein binding
  • transmembrane signaling receptor activity
  • phosphatidylinositol-4,5-bisphosphate binding
  • G protein-coupled receptor activity
  • Wnt-activated receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • recycling endosome membrane
  • endosome
  • endosome membrane
Biological process
  • negative regulation of cell-substrate adhesion
  • cellular response to retinoic acid
  • G protein-coupled receptor signaling pathway
  • non-canonical Wnt signaling pathway
  • regulation of transcription, DNA-templated
  • positive regulation of epithelial cell proliferation involved in wound healing
  • T cell differentiation in thymus
  • non-canonical Wnt signaling pathway via JNK cascade
  • negative regulation of ectodermal cell fate specification
  • somatic stem cell division
  • positive regulation of JNK cascade
  • Wnt signaling pathway
  • stem cell population maintenance
  • positive regulation of transcription, DNA-templated
  • multicellular organism development
  • cell surface receptor signaling pathway
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
  • neuron differentiation
  • canonical Wnt signaling pathway
  • substrate adhesion-dependent cell spreading
  • positive regulation of phosphorylation
  • signal transduction
  • mesenchymal to epithelial transition
  • Wnt signaling pathway, planar cell polarity pathway
  • negative regulation of cardiac muscle cell differentiation
  • regulation of canonical Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8324

14369

Ensembl

ENSG00000155760

ENSMUSG00000041075

UniProt

O75084

Q61090

RefSeq (mRNA)

NM_003507

NM_008057

RefSeq (protein)

NP_003498

NP_032083

Location (UCSC)Chr 2: 202.03 – 202.04 MbChr 1: 59.52 – 59.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.[5][6][7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[7]

Interactions

Fz-7 has been shown to interact with DLG4.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155760 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041075 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
  6. ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
  7. ^ a b "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
  8. ^ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3). Netherlands: 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714. S2CID 39243103.

Further reading

  • Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
  • Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. S2CID 39243103.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene. 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation. 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Vincan E, Darcy PK, Farrelly CA, et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene. 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
  • Struewing IT, Barnett CD, Zhang W, et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.

External links

  • "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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