GPBP1

Protein-coding gene in the species Homo sapiens
GPBP1
Identifiers
AliasesGPBP1, GPBP, SSH6, VASCULIN, GC-rich promoter binding protein 1
External IDsOMIM: 608412; MGI: 1920524; HomoloGene: 11292; GeneCards: GPBP1; OMA:GPBP1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for GPBP1
Genomic location for GPBP1
Band5q11.2Start57,173,948 bp[1]
End57,264,679 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for GPBP1
Genomic location for GPBP1
Band13|13 D2.2Start111,562,214 bp[2]
End111,626,645 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • cardiac muscle tissue of right atrium

  • Achilles tendon

  • corpus callosum

  • gonad

  • myocardium of left ventricle

  • mucosa of paranasal sinus

  • epithelium of nasopharynx

  • ganglionic eminence

  • mucosa of ileum
Top expressed in
  • zygote

  • primary oocyte

  • secondary oocyte

  • blood

  • cumulus cell

  • tail of embryo

  • spermatid

  • medial ganglionic eminence

  • hand

  • vestibular sensory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • protein binding
Cellular component
  • cytoplasm
  • intracellular membrane-bounded organelle
  • nucleus
  • cytosol
  • plasma membrane
Biological process
  • positive regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

65056

73274

Ensembl

ENSG00000062194

ENSMUSG00000032745

UniProt

Q86WP2

Q6NXH3

RefSeq (mRNA)

NM_001127235
NM_001127236
NM_001203246
NM_022913
NM_001331037

NM_001122963
NM_028487
NM_001361923
NM_001361924
NM_001361925

NM_001361926

RefSeq (protein)

NP_001120707
NP_001120708
NP_001190175
NP_001317966
NP_075064

NP_001116435
NP_082763
NP_001348852
NP_001348853
NP_001348854

NP_001348855

Location (UCSC)Chr 5: 57.17 – 57.26 MbChr 13: 111.56 – 111.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vasculin is a protein that in humans is encoded by the GPBP1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000062194 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032745 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bijnens AP, Gils A, Jutten B, Faber BC, Heeneman S, Kitslaar PJ, Tordoir JH, de Vries CJ, Kroon AA, Daemen MJ, Cleutjens KB (Oct 2003). "Vasculin, a novel vascular protein differentially expressed in human atherogenesis". Blood. 102 (8): 2803–10. doi:10.1182/blood-2003-01-0306. PMID 12842993.
  6. ^ "Entrez Gene: GPBP1 GC-rich promoter binding protein 1".

Further reading

  • Szafranski K, Schindler S, Taudien S, et al. (2008). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Hsu LC, Liu S, Abedinpour F, et al. (2003). "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription". Mol. Cell. Biol. 23 (23): 8773–85. doi:10.1128/MCB.23.23.8773-8785.2003. PMC 262660. PMID 14612417.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


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