GZMB

Protein-coding gene in the species Homo sapiens
GZMB
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1FQ3, 1IAU

Identifiers
AliasesGZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDsOMIM: 123910; MGI: 109267; HomoloGene: 108184; GeneCards: GZMB; OMA:GZMB - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for GZMB
Genomic location for GZMB
Band14q12Start24,630,954 bp[1]
End24,634,267 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for GZMB
Genomic location for GZMB
Band14 C3|14 28.19 cMStart56,496,295 bp[2]
End56,499,717 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • monocyte

  • spleen

  • bone marrow

  • lymph node

  • right lung

  • appendix

  • palpebral conjunctiva

  • upper lobe of left lung

  • bone marrow cells
Top expressed in
  • jejunum

  • duodenum

  • blood

  • intestinal villus

  • pharynx

  • uterus

  • seminal vesicula

  • right lung lobe

  • submandibular gland

  • spleen
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • peptidase activity
  • protein binding
  • serine-type peptidase activity
  • serine-type endopeptidase activity
  • hydrolase activity
Cellular component
  • cytosol
  • membrane
  • immunological synapse
  • nucleus
  • mitochondrion
  • secretory granule
  • cytoplasm
Biological process
  • cytolysis
  • proteolysis
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  • natural killer cell mediated cytotoxicity
  • apoptotic process
  • granzyme-mediated apoptotic signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3002

14939

Ensembl

ENSG00000100453

ENSMUSG00000015437

UniProt

P10144

P04187

RefSeq (mRNA)

NM_004131
NM_001346011

NM_013542

RefSeq (protein)

NP_001332940
NP_004122

NP_038570

Location (UCSC)Chr 14: 24.63 – 24.63 MbChr 14: 56.5 – 56.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[5] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.
  6. ^ "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

Further reading

  • Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.". Australian and New Zealand Journal of Medicine. 25 (6): 793–9. doi:10.1111/j.1445-5994.1995.tb02883.x. PMID 8770355.
  • Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. 326 (1): 1–16. doi:10.1042/bj3260001. PMC 1218630. PMID 9337844.
  • Trapani JA, Sutton VR (2004). "Granzyme B: pro-apoptotic, antiviral and antitumor functions". Curr. Opin. Immunol. 15 (5): 533–43. doi:10.1016/S0952-7915(03)00107-9. PMID 14499262.

External links

  • The MEROPS online database for peptidases and their inhibitors: S01.010
  • v
  • t
  • e
  • 1fq3: CRYSTAL STRUCTURE OF HUMAN GRANZYME B
    1fq3: CRYSTAL STRUCTURE OF HUMAN GRANZYME B
  • 1iau: HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO
    1iau: HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO
Stub icon

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e