HLTF

HLTF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MZN, 4HRE, 4HRH, 4S0N, 4XZF, 4XZG, 5BNH, 5K5F
Identifiers
Aliases	HLTF, HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1, helicase-like transcription factor, helicase like transcription factor
External IDs	OMIM: 603257; MGI: 1196437; HomoloGene: 30136; GeneCards: HLTF; OMA:HLTF - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q24 Start 149,030,127 bp[1] End 149,086,554 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A2|3 6.15 cM Start 20,111,975 bp[2] End 20,172,654 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pons lateral nuclear group of thalamus Pars compacta Epithelium of choroid plexus pars reticulata subthalamic nucleus superior vestibular nucleus external globus pallidus cerebellar vermis Top expressed in saccule otic placode otic vesicle habenula atrioventricular valve transitional epithelium of urinary bladder mesenteric lymph nodes retinal pigment epithelium blood primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity protein binding catalytic activity nucleic acid binding hydrolase activity ATP binding ubiquitin protein ligase binding transferase activity RNA binding ubiquitin protein ligase activity Cellular component cytoplasm membrane nucleolus nucleus nucleoplasm Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated metabolism positive regulation of transcription by RNA polymerase II protein ubiquitination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6596 20585 Ensembl ENSG00000071794 ENSMUSG00000002428 UniProt Q14527 Q6PCN7 RefSeq (mRNA) NM_003071 NM_139048 NM_001318934 NM_001318935 NM_009210 NM_144959 NM_001355097 RefSeq (protein) NP_001305863 NP_001305864 NP_003062 NP_620636 NP_033236 NP_001342026 Location (UCSC) Chr 3: 149.03 – 149.09 Mb Chr 3: 20.11 – 20.17 Mb PubMed search [3] [4]
Wikidata
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Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene.^[5][6]

Function

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.^[6]

HLTF is a double-stranded DNA translocase, one of two human homologs of Saccharomyces cerevisiae RAD5 besides SHPRH (SNF2 histone linker PHD RING helicase), that is able to carry out fork regression, similarly to Rad5.^[7]

Interactions

HLTF has been shown to interact with UBE2N,^[8] RAD18^[8] and UBE2V2^[8](see also STRING functional and physical associations network : under the option 'search by name' enter 'protein name' of interest, HLTF, klick on 'GO! ', choose 'organism ', klick on 'continue ->' ).

References

Further reading