IQCB1

Protein-coding gene in the species Homo sapiens
IQCB1
Identifiers
AliasesIQCB1, NPHP5, PIQ, SLSN5, IQ motif containing B1
External IDsOMIM: 609237; MGI: 2443764; HomoloGene: 8766; GeneCards: IQCB1; OMA:IQCB1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for IQCB1
Genomic location for IQCB1
Band3q13.33|3q21.1Start121,769,761 bp[1]
End121,835,079 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for IQCB1
Genomic location for IQCB1
Band16|16 B3Start36,648,747 bp[2]
End36,693,083 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • epithelium of nasopharynx

  • testicle

  • monocyte

  • ventricular zone

  • body of pancreas

  • Achilles tendon

  • olfactory zone of nasal mucosa

  • rectum

  • bronchial epithelial cell
Top expressed in
  • neural layer of retina

  • genital tubercle

  • hand

  • zygote

  • spermatocyte

  • tail of embryo

  • dentate gyrus of hippocampal formation granule cell

  • neural tube

  • ventricular zone

  • secondary oocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • enzyme binding
  • protein binding
  • calmodulin binding
Cellular component
  • cytoplasm
  • microtubule organizing center
  • cytosol
  • centrosome
  • photoreceptor outer segment
  • extracellular exosome
  • cytoskeleton
  • photoreceptor connecting cilium
  • centriole
  • nucleoplasm
  • microtubule cytoskeleton
  • intercellular bridge
  • mitotic spindle
Biological process
  • photoreceptor cell maintenance
  • maintenance of animal organ identity
  • cell projection organization
  • cilium assembly
  • ciliary basal body-plasma membrane docking
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9657

320299

Ensembl

ENSG00000173226

ENSMUSG00000022837

UniProt

Q15051

Q8BP00

RefSeq (mRNA)

NM_001023570
NM_001023571
NM_001319107
NM_014642

NM_177128

RefSeq (protein)

NP_001018864
NP_001018865
NP_001306036

NP_796102

Location (UCSC)Chr 3: 121.77 – 121.84 MbChr 16: 36.65 – 36.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173226 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022837 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Otto EA, Loeys B, Khanna H, Hellemans J, Sudbrak R, Fan S, Muerb U, O'Toole JF, Helou J, Attanasio M, Utsch B, Sayer JA, Lillo C, Jimeno D, Coucke P, De Paepe A, Reinhardt R, Klages S, Tsuda M, Kawakami I, Kusakabe T, Omran H, Imm A, Tippens M, Raymond PA, Hill J, Beales P, He S, Kispert A, Margolis B, Williams DS, Swaroop A, Hildebrandt F (Feb 2005). "Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin". Nat Genet. 37 (3): 282–8. doi:10.1038/ng1520. PMID 15723066. S2CID 4972004.
  6. ^ "Entrez Gene: IQCB1 IQ motif containing B1".

Further reading

  • Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  • Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Mollet G, Salomon R, Gribouval O, et al. (2002). "The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin". Nat. Genet. 32 (2): 300–5. doi:10.1038/ng996. PMID 12244321. S2CID 24216974.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mollet G, Silbermann F, Delous M, et al. (2005). "Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes". Hum. Mol. Genet. 14 (5): 645–56. doi:10.1093/hmg/ddi061. PMID 15661758.
  • le Maire A, Weber T, Saunier S, et al. (2006). "Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis". Proteins. 59 (2): 347–55. doi:10.1002/prot.20344. PMID 15723349. S2CID 37333782.
  • Luo X, He Q, Huang Y, Sheikh MS (2006). "Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers". Cancer Res. 65 (23): 10725–33. doi:10.1158/0008-5472.CAN-05-1132. PMID 16322217.


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