LIMA1

Protein-coding gene in humans

LIMA1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2D8Y

Identifiers

Aliases

LIMA1, EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8

External IDs

OMIM: 608364; MGI: 1920992; HomoloGene: 9484; GeneCards: LIMA1; OMA:LIMA1 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.12	Start	50,175,788 bp^[1]
Band	12q13.12	End	50,283,546 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15 F1\|15 56.13 cM	Start	99,676,351 bp^[2]
Band	15 F1\|15 56.13 cM	End	99,773,337 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

secondary oocyte

tendon of biceps brachii

Achilles tendon

rectum

mucosa of colon

mucosa of sigmoid colon

subcutaneous adipose tissue

jejunal mucosa

gastric mucosa

Top expressed in

genital tubercle

lacrimal gland

transitional epithelium of urinary bladder

Rostral migratory stream

left colon

epithelium of stomach

lobe of prostate

duodenum

pyloric antrum

corneal stroma

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	actin filament binding actin binding actin monomer binding protein binding metal ion binding cadherin binding
Cellular component	cell junction cleavage furrow cytoskeleton brush border stress fiber focal adhesion actin cytoskeleton cytoplasm
Biological process	negative regulation of actin filament depolymerization ruffle organization actin filament bundle assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51474


65970

Ensembl


ENSG00000050405


ENSMUSG00000023022

UniProt


Q9UHB6


Q9ERG0

RefSeq (mRNA)


NM_001113546 NM_001113547 NM_001243775 NM_016357


NM_001113545 NM_023063

RefSeq (protein)


NP_001107018 NP_001107019 NP_001230704 NP_057441


NP_001107017 NP_075550

Location (UCSC)

Chr 12: 50.18 – 50.28 Mb

Chr 15: 99.68 – 99.77 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.^[5]^[6]^[7]^[8]

EPLIN is a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles (Maul et al., 2003).[supplied by OMIM]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000050405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023022 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen S, Maul RS, Kim HR, Chang DD (Jul 2000). "Characterization of the human EPLIN (Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms". Gene. 248 (1–2): 69–76. doi:10.1016/S0378-1119(00)00144-X. PMID 10806352.
^ Maul RS, Chang DD (Feb 2000). "EPLIN, epithelial protein lost in neoplasm". Oncogene. 18 (54): 7838–41. doi:10.1038/sj.onc.1203206. PMID 10618726.
^ Maul RS, Song Y, Amann KJ, Gerbin SC, Pollard TD, Chang DD (Feb 2003). "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments". J Cell Biol. 160 (3): 399–407. doi:10.1083/jcb.200212057. PMC 2172667. PMID 12566430.
^ ^a ^b "Entrez Gene: LIMA1 LIM domain and actin binding 1".

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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
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