MIER1

Protein-coding gene in the species Homo sapiens
MIER1
Identifiers
AliasesMIER1, ER1, MI-ER1, MIER1 transcriptional regulator
External IDsOMIM: 616848; MGI: 1918398; HomoloGene: 136176; GeneCards: MIER1; OMA:MIER1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MIER1
Genomic location for MIER1
Band1p31.3Start66,924,895 bp[1]
End66,988,619 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for MIER1
Genomic location for MIER1
Band4|4 C6Start102,971,587 bp[2]
End103,022,951 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • epithelium of colon

  • mucosa of ileum

  • sural nerve

  • bone marrow

  • bone marrow cells

  • mucosa of colon

  • mucosa of sigmoid colon

  • skin of arm

  • tail of epididymis
Top expressed in
  • hand

  • superior cervical ganglion

  • thymus

  • Gonadal ridge

  • tail of embryo

  • genital tubercle

  • interventricular septum

  • mesenteric lymph nodes

  • left colon

  • blood
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • signal transducer activity
  • histone deacetylase activity
  • histone deacetylase binding
Cellular component
  • cytoplasm
  • transcription repressor complex
  • nucleoplasm
  • nucleus
Biological process
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • signal transduction
  • histone deacetylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57708

71148

Ensembl

ENSG00000198160

ENSMUSG00000028522

UniProt

Q8N108

Q5UAK0

RefSeq (mRNA)
NM_001077700
NM_001077701
NM_001077702
NM_001077703
NM_001077704

NM_001146110
NM_001146111
NM_001146112
NM_001146113
NM_001278215
NM_020948
NM_001350530

NM_001039081
NM_001286221
NM_001286222
NM_001286223
NM_027696

RefSeq (protein)
NP_001071168
NP_001071169
NP_001071170
NP_001071171
NP_001071172

NP_001139582
NP_001139583
NP_001139584
NP_001139585
NP_001265144
NP_065999
NP_001337459

NP_001034170
NP_001273150
NP_001273151
NP_001273152
NP_081972

NP_001391009
NP_001391010
NP_001391011
NP_001391013
NP_001391014

Location (UCSC)Chr 1: 66.92 – 66.99 MbChr 4: 102.97 – 103.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mesoderm induction early response protein 1 is a protein that in humans is encoded by the MIER1 gene.[5][6][7]

Interactions

MIER1 has been shown to interact with HDAC1.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198160 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028522 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, Gillespie LL (Jul 2002). "Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization". Gene. 295 (1): 79–88. doi:10.1016/S0378-1119(02)00823-5. PMID 12242014.
  6. ^ a b Ding Z, Gillespie LL, Paterno GD (Jan 2003). "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology. 23 (1): 250–8. doi:10.1128/MCB.23.1.250-258.2003. PMC 140656. PMID 12482978.
  7. ^ "Entrez Gene: MIER1 mesoderm induction early response 1 homolog (Xenopus laevis)".

Further reading

  • Paterno GD, Mercer FC, Chayter JJ, Yang X, Robb JD, Gillespie LL (Nov 1998). "Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines". Gene. 222 (1): 77–82. doi:10.1016/S0378-1119(98)00473-9. PMID 9813250.
  • Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
  • Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
  • Ding Z, Gillespie LL, Mercer FC, Paterno GD (Jul 2004). "The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter". The Journal of Biological Chemistry. 279 (27): 28009–16. doi:10.1074/jbc.M403793200. PMID 15117948.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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