MLLT3

Protein-coding gene in the species Homo sapiens
MLLT3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2LM0, 2MV7, 4TMP, 2N4Q, 5HJB, 5HJD

Identifiers
AliasesMLLT3, AF9, YEATS3, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, super elongation complex subunit, MLLT3 super elongation complex subunit
External IDsOMIM: 159558; MGI: 1917372; HomoloGene: 37933; GeneCards: MLLT3; OMA:MLLT3 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for MLLT3
Genomic location for MLLT3
Band9p21.3Start20,341,669 bp[1]
End20,622,499 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for MLLT3
Genomic location for MLLT3
Band4 C4|4 41.06 cMStart87,688,162 bp[2]
End87,951,601 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • rectum

  • Achilles tendon

  • epithelium of colon

  • endothelial cell

  • ventricular zone

  • buccal mucosa cell

  • testicle

  • mucosa of transverse colon

  • stromal cell of endometrium
Top expressed in
  • tail of embryo

  • genital tubercle

  • zygote

  • metatarsal bones

  • plantaris muscle

  • muscle of thigh

  • extensor digitorum longus muscle

  • intercostal muscle

  • Ileal epithelium

  • triceps brachii muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • chromatin binding
  • histone binding
  • lysine-acetylated histone binding
  • modification-dependent protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • transcription elongation factor complex
  • extracellular exosome
  • nucleus
  • nucleoplasm
  • chromosome
Biological process
  • positive regulation of Wnt signaling pathway, planar cell polarity pathway
  • regulation of transcription, DNA-templated
  • negative regulation of canonical Wnt signaling pathway
  • transcription, DNA-templated
  • segment specification
  • anterior/posterior pattern specification
  • transcription by RNA polymerase II
  • transcription elongation from RNA polymerase II promoter
  • positive regulation of transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4300

70122

Ensembl

ENSG00000171843

ENSMUSG00000028496

UniProt

P42568

A2AM29

RefSeq (mRNA)

NM_004529
NM_001286691

NM_001286158
NM_027326
NM_029931

RefSeq (protein)

NP_001273620
NP_004520

NP_001273087
NP_081602
NP_084207
NP_001391884
NP_001391885

NP_001391886
NP_001391887

Location (UCSC)Chr 9: 20.34 – 20.62 MbChr 4: 87.69 – 87.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.[5][6][7]


Interactions

MLLT3 has been shown to interact with BCOR.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171843 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028496 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A. 90 (10): 4631–5. Bibcode:1993PNAS...90.4631N. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.
  6. ^ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene. 8 (11): 3085–92. PMID 8414510.
  7. ^ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".
  8. ^ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810. PMC 316791. PMID 10898795.
  • García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
  • Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Srinivasan RS, de Erkenez AC, Hemenway CS (2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. PMID 12776190.
  • Erfurth F, Hemenway CS, de Erkenez AC, Domer PH (2004). "MLL fusion partners AF4 and AF9 interact at subnuclear foci". Leukemia. 18 (1): 92–102. doi:10.1038/sj.leu.2403200. PMID 14603337.
  • Montemurro L, Tonelli R, Fazzina R, et al. (2004). "Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line". Cancer Genet. Cytogenet. 154 (1): 96–7. doi:10.1016/j.cancergencyto.2004.01.029. PMID 15381384.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Martino V, Tonelli R, Montemurro L, et al. (2006). "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)". Oncol. Rep. 15 (1): 207–11. doi:10.3892/or.15.1.207. PMID 16328057.


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