SIGLEC10

Protein-coding gene in the species Homo sapiens
SIGLEC10
Identifiers
AliasesSIGLEC10, PRO940, SIGLEC-10, SLG2, sialic acid binding Ig like lectin 10
External IDsOMIM: 606091; MGI: 2443630; HomoloGene: 13228; GeneCards: SIGLEC10; OMA:SIGLEC10 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SIGLEC10
Genomic location for SIGLEC10
Band19q13.41Start51,410,020 bp[1]
End51,417,803 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SIGLEC10
Genomic location for SIGLEC10
Band7|7 B3Start43,057,628 bp[2]
End43,067,782 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • blood

  • appendix

  • spleen

  • oocyte

  • secondary oocyte

  • lymph node

  • buccal mucosa cell

  • right adrenal cortex
Top expressed in
  • spleen

  • blood

  • subcutaneous adipose tissue

  • bone marrow

  • pharynx

  • morula

  • submandibular gland

  • white adipose tissue

  • blastocyst

  • thymus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • carbohydrate binding
  • protein binding
  • phosphatase binding
  • SH2 domain binding
Cellular component
  • integral component of membrane
  • extracellular region
  • membrane
  • plasma membrane
Biological process
  • cell adhesion
  • adaptive immune response
  • immune system process
  • innate immune response
  • negative regulation of inflammatory response to wounding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89790

243958

Ensembl

ENSG00000142512

ENSMUSG00000030468

UniProt

Q96LC7

Q80ZE3

RefSeq (mRNA)
NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160

NM_001171161
NM_033130
NM_001322105

NM_172900
NM_001382486

RefSeq (protein)
NP_001164627
NP_001164628
NP_001164629
NP_001164630
NP_001164632

NP_001309034
NP_149121

NP_766488
NP_001369415

Location (UCSC)Chr 19: 51.41 – 51.42 MbChr 7: 43.06 – 43.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.[5][6] Siglec-G is often referred to as the murine paralog of human Siglec-10 [7]

Structure and function

Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab.[8] It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

Gene family summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142512 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030468 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR (Apr 2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor". Biochem J. 355 (Pt 2): 489–97. doi:10.1042/0264-6021:3550489. PMC 1221762. PMID 11284738.
  6. ^ a b "Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10".
  7. ^ Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H (Nov 2018). "Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells". J. Clin. Invest. 128 (Pt 11): 4912–23. doi:10.1172/JCI120612. PMC 6205408. PMID 30130255.
  8. ^ Clark, M. & A. Cooke (2013). "Regulation unmasked by activation". Nat Immunol. 14 (7): 696–697. doi:10.1038/ni.2646. PMID 23778805. S2CID 11457712.

Further reading

  • Li N, Zhang W, Wan T, et al. (2001). "Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells". J. Biol. Chem. 276 (30): 28106–12. doi:10.1074/jbc.M100467200. PMID 11358961.
  • Yousef GM, Ordon MH, Foussias G, Diamandis EP (2001). "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants". Biochem. Biophys. Res. Commun. 284 (4): 900–10. doi:10.1006/bbrc.2001.5053. PMID 11409878.
  • Nagano T, Yoneda T, Hatanaka Y, et al. (2002). "Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone". Nat. Cell Biol. 4 (7): 495–501. doi:10.1038/ncb808. PMID 12055638. S2CID 4795393.
  • Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J (2002). "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1". Biochem. Biophys. Res. Commun. 296 (2): 355–62. doi:10.1016/S0006-291X(02)00885-9. PMID 12163025.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
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