Sulfamerazine

Chemical compound
  • D06BA06 (WHO) J01ED07 (WHO) QJ01EQ17 (WHO)
Identifiers
  • 4-amino-N-(4-methylpyrimidin-2-yl)
    benzenesulfonamide
CAS Number
  • 127-79-7 checkY
PubChem CID
  • 5325
DrugBank
  • DB01581 checkY
ChemSpider
  • 5134 checkY
UNII
  • UR1SAB295F
KEGG
  • D02435 checkY
ChEBI
  • CHEBI:102130 checkY
ChEMBL
  • ChEMBL438 checkY
CompTox Dashboard (EPA)
  • DTXSID0023612 Edit this at Wikidata
ECHA InfoCard100.004.425 Edit this at WikidataChemical and physical dataFormulaC11H12N4O2SMolar mass264.30 g·mol−13D model (JSmol)
  • Interactive image
Melting point234 to 238 °C (453 to 460 °F)
  • O=S(=O)(Nc1nc(ccn1)C)c2ccc(N)cc2
InChI
  • InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) checkY
  • Key:QPPBRPIAZZHUNT-UHFFFAOYSA-N checkY
  (verify)

Sulfamerazine is a sulfonamide antibacterial.

Synthesis

Sulfamerazine synthesis:[1][2] U.S. patent 2,378,813

See also

References

  1. ^ Roblin RO, Williams JH, Winnek PS, English JP (1940). "Chemotherapy. II. Some Sulfanilamido Heterocycles1". Journal of the American Chemical Society. 62 (8): 2002–2005. doi:10.1021/ja01865a027.
  2. ^ Sprague JM, Kissinger LW, Lincoln RM (1941). "Sulfonamido Derivatives of Pyrimidines". Journal of the American Chemical Society. 63 (11): 3028–3030. doi:10.1021/ja01856a046.

External links

Media related to Sulfamerazine at Wikimedia Commons

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Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor
Sulfonamides
(DHPS inhibitor)
Short-acting
Intermediate-acting
Long-acting
Other/ungrouped
Combinations
Other DHPS inhibitors
Quinolones
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)
1st generation
Fluoroquinolones
2nd generation
3rd generation
4th generation
Veterinary
Newer non-fluorinated
Related (DG)
Anaerobic DNA
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Nitrofuran derivatives
RNA synthesis
Rifamycins/
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Lipiarmycins
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