Tizoxanide

Tizoxanide
Names
Preferred IUPAC name
2-Hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
Other names
Desacetyl-nitazoxanide
Identifiers
CAS Number
  • 173903-47-4 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL1545 checkY
ChemSpider
  • 349588 checkY
ECHA InfoCard 100.263.225 Edit this at Wikidata
PubChem CID
  • 394397
UNII
  • 15KFG88UOJ checkY
CompTox Dashboard (EPA)
  • DTXSID40169680 Edit this at Wikidata
InChI
  • InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15) checkY
    Key: FDTZUTSGGSRHQF-UHFFFAOYSA-N checkY
  • InChI=1/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)
    Key: FDTZUTSGGSRHQF-UHFFFAOYAR
  • O=C(Nc1ncc(s1)[N+]([O-])=O)c2ccccc2O
Properties
Chemical formula
 C10H7N3O4S
Molar mass 265.25 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Tizoxanide, also known as desacetyl-nitazoxanide, is a thiazolide and an antiparasitic agent that occurs as a metabolite of nitazoxanide in humans through hydrolysis.[1] Tizoxanide may undergo further metabolism via conjugation into tizoxanide glucuronide.[2][3]

References

  1. ^ Korba BE, Montero AB, Farrar K, et al. (January 2008). "Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication". Antiviral Res. 77 (1): 56–63. doi:10.1016/j.antiviral.2007.08.005. PMID 17888524.
  2. ^ "Nitazoxanide Prescribing Information" (PDF). Romark Pharmaceuticals. August 2013. pp. 1–5. Retrieved 3 January 2016.
  3. ^ Stockis A, Allemon AM, De Bruyn S, Gengler C (May 2002). "Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses". Int J Clin Pharmacol Ther. 40 (5): 213–220. doi:10.5414/cpp40213. PMID 12051573.
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