NPR2

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Natriuretski peptidni receptor B/guanilat ciklaza B (atrionatriuretski peptidni receptor B)
Identifikatori
SimboliNPR2; AMDM; ANPRB; ANPb; GUC2B; GUCY2B; NPRB; NPRBi
Vanjski IDOMIM: 108961 MGI: 97372 HomoloGene: 2970 GeneCards: NPR2 Gene
EC broj4.6.1.2
Ontologija gena
Molekularna funkcija aktivnost guanilatne ciklaze
aktivnost proteinske kinaze
receptorska aktivnost
Celularna komponenta intracelularno
ćelijska membrana
integralno sa membranom
Biološki proces osifikacija
cGMP biosintetički proces
prenos signala
Ortolozi
VrstaČovekMiš
Entrez4882230103
EnsemblENSG00000159899ENSMUSG00000028469
UniProtP20594Q6VVW5
RefSeq (mRNA)NM_000907.2NM_173788.3
RefSeq (protein)NP_003986.2NP_776149.1
Lokacija (UCSC)Chr 9:
35.79 - 35.81 Mb
Chr 4:
43.63 - 43.65 Mb
PubMed pretraga[1][2]

Natriuretski peptidni receptor B (atrionatriuretski peptidni receptor B, NPR2) je receptor atrijalnog natriuretskog peptida. Ovaj receptor je kod čoveka kodiran NPR1 genom.[1]

Reference

  1. „Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)”. 

Literatura

  • Fox AA, Collard CD, Shernan SK, et al. (2009). „Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.”. Anesthesiology 110 (4): 738–47. DOI:10.1097/ALN.0b013e31819c7496. PMC 2735337. PMID 19326473. 
  • Potthast R, Abbey-Hosch SE, Antos LK, et al. (2004). „Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B.”. J. Biol. Chem. 279 (47): 48513–9. DOI:10.1074/jbc.M408247200. PMID 15371450. 
  • Liew D, Schneider H, D'Agostino J, et al. (2004). „Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al.”. Diabetes Care 27 (3): 848; author reply 848–9. DOI:10.2337/diacare.27.3.848. PMID 14988324. 
  • Antos LK, Abbey-Hosch SE, Flora DR, Potter LR (2005). „ATP-independent activation of natriuretic peptide receptors.”. J. Biol. Chem. 280 (29): 26928–32. DOI:10.1074/jbc.M505648200. PMID 15911610. 
  • Poreba R, Poczatek K, Gać P, et al. (2009). „SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension.”. Pol. Arch. Med. Wewn. 119 (4): 219–24. PMID 19413180. 
  • Koller KJ, Goeddel DV (1992). „Molecular biology of the natriuretic peptides and their receptors.”. Circulation 86 (4): 1081–8. PMID 1327579. 
  • Fan D, Bryan PM, Antos LK, et al. (2005). „Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.”. Mol. Pharmacol. 67 (1): 174–83. DOI:10.1124/mol.104.002436. PMID 15459247. 
  • Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH (2007). „Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy.”. J. Mol. Med. 85 (8): 797–810. DOI:10.1007/s00109-007-0183-4. PMID 17429599. 
  • Rahmutula D, Cui J, Chen S, Gardner DG (2004). „Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1.”. Hypertension 44 (3): 283–8. DOI:10.1161/01.HYP.0000136908.60317.92. PMID 15262909. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). „DNA sequence and analysis of human chromosome 9.”. Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053. 
  • Hume AN, Buttgereit J, Al-Awadhi AM, et al. (2009). „Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux.”. Hum. Mol. Genet. 18 (2): 267–77. DOI:10.1093/hmg/ddn354. PMC 2638773. PMID 18945719. 
  • Schulz S (2005). „C-type natriuretic peptide and guanylyl cyclase B receptor.”. Peptides 26 (6): 1024–34. DOI:10.1016/j.peptides.2004.08.027. PMID 15911070. 
  • Tsuji T, Kunieda T (2005). „A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse.”. J. Biol. Chem. 280 (14): 14288–92. DOI:10.1074/jbc.C500024200. PMID 15722353. 
  • Dickey DM, Yoder AR, Potter LR (2009). „A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.”. J. Biol. Chem. 284 (29): 19196–202. DOI:10.1074/jbc.M109.010777. PMC 2740543. PMID 19458086. 
  • Nozohoor S, Nilsson J, Lührs C, et al. (2009). „B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement.”. J. Cardiothorac. Vasc. Anesth. 23 (2): 161–5. DOI:10.1053/j.jvca.2008.11.006. PMID 19167912. 
  • Hachiya R, Ohashi Y, Kamei Y, et al. (2007). „Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development.”. J. Clin. Endocrinol. Metab. 92 (10): 4009–14. DOI:10.1210/jc.2007-1101. PMID 17652215. 
  • Gratacòs M, Costas J, de Cid R, et al. (2009). „Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. DOI:10.1002/ajmg.b.30902. PMID 19086053. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Bartels CF, Bükülmez H, Padayatti P, et al. (2004). „Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux.”. Am. J. Hum. Genet. 75 (1): 27–34. DOI:10.1086/422013. PMC 1182004. PMID 15146390. 
  • van den Akker F (2001). „Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors.”. J. Mol. Biol. 311 (5): 923–37. DOI:10.1006/jmbi.2001.4922. PMID 11556325. 

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Spoljašnje veze

  • MeSH NPR2+protein,+human
  • p
  • r
  • u
Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptoriDrugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)