PICK1

edit

Protein koji interaguje sa PRKCA 1

PDB prikaz baziran na 2gzv.

Dostupne strukture

2GZV

Identifikatori

Simboli

PICK1; PICK; PRKCABP

Vanjski ID

OMIM: 605926 MGI: 894645 HomoloGene: 7470 GeneCards: PICK1 Gene

Ontologija gena
Molekularna funkcija	• vezivanje proteinske kinaze C • vezivanje receptora • proteinsko vezivanje • vezivanje proteinskog C-terminusa • ATPazna aktivnost • enzimsko vezivanje • vezivanje specifično za proteinski domen • vezivanje identičnih proteina • vezivanje metalnog jona
Celularna komponenta	• citoplazma • mitohondrija • Goldžijev aparat • ćelijska membrana • postsinaptčka gustina • sinaptozom • ćelijski spoj • dendrit • membrana endocitne vezikule • presinaptička membrana • proteinski kompleks • sinapsa • perinuklearni region citoplazme
Biološki proces	• ATP katabolički proces • proteinska fosforilacija • proteinsko ciljanje • retrogradni vezikulom posredovani transport, Goldži do ER • aktivacija aktivnosti proteinske kinaze C putem signalnog puta G protein spregnutog receptora • sinaptička transmisija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

9463

18693

Ensembl

ENSG00000100151

ENSMUSG00000068206

UniProt

Q9NRD5

Q62083

RefSeq (mRNA)

NM_001039583.1

NM_001045558.1

RefSeq (protein)

NP_001034672.1

NP_001039023.1

Lokacija (UCSC)

Chr 22:
38.45 - 38.47 Mb

Chr 15:
79.06 - 79.09 Mb

PubMed pretraga

[1]

[2]

PICK1 (PRKCA vezujući protein) je protein koji je kod ljudi kodiran PICK1 genom.^[1]^[2]

Protein kodiran ovim genom sadrži PDZ domen, putem kojeg formira interakcije sa proteinskom kinazom C, alfa (PRKCA). Ovaj protein može da funkcioniše kao adapter koji se vezuje za razne membranske proteine i organizuje njihovu ćelijsku lokalizaciju. On interaguje sa više tipova glutamatnog receptora, monoaminskim ćelijskim transporterima, kao i natrijumskim kanalima koji nisu kontrolisani naponom. Ovaj protein takođe deluje kao fiksirajući protein koji specifično vezuje PRKCA za mitohondrije pod uticajem specifičnih liganda. Postoje tri transkriptne varijante koje kodiraju isti protein.^[3]

Interakcije

PICK1 formira interakcije sa HER2/neu,^[4] ACCN2,^[5]^[6] metabotropni glutamatni receptor 7,^[7] BNC1,^[6] metabotropni glutamatni receptor 3,^[8] GRIA4,^[8] dopaminski transporter,^[9] GRIK1,^[10] GRIK2,^[10] GRIK3,^[8] GRIA2^[8] i GRIA3.^[8]

Reference

↑ Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). „The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits”. Neuropharmacology 38 (5): 635-44. DOI:10.1016/S0028-3908(98)00230-5. PMID 10340301.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM i dr.. (December 1999). „The DNA sequence of human chromosome 22”. Nature 402 (6761): 489-95. DOI:10.1038/990031. PMID 10591208.
↑ „Entrez Gene: PICK1 protein interacting with PRKCA 1”.
↑ Jaulin-Bastard, F; Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg J P (May 2001). „The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins”. J. Biol. Chem. (United States) 276 (18): 15256-63. DOI:10.1074/jbc.M010032200. ISSN 0021-9258. PMID 11278603.
↑ Leonard, A Soren; Yermolaieva Olena, Hruska-Hageman Alesia, Askwith Candice C, Price Margaret P, Wemmie John A, Welsh Michael J (February 2003). „cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1”. Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (4): 2029-34. DOI:10.1073/pnas.252782799. ISSN 0027-8424. PMC 149953. PMID 12578970.
↑ ^6,0 ^6,1 Hruska-Hageman, Alesia M; Wemmie John A, Price Margaret P, Welsh Michael J (February 2002). „Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)”. Biochem. J. (England) 361 (Pt 3): 443-50. DOI:10.1042/0264-6021:3610443. ISSN 0264-6021. PMC 1222326. PMID 11802773.
↑ Dev, K K; Nakajima Y, Kitano J, Braithwaite S P, Henley J M, Nakanishi S (October 2000). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. (UNITED STATES) 20 (19): 7252-7. PMID 11007882.
↑ ^8,0 ^8,1 ^8,2 ^8,3 ^8,4 Hirbec, Hélène; Perestenko Olga, Nishimune Atsushi, Meyer Guido, Nakanishi Shigetada, Henley Jeremy M, Dev Kumlesh K (May 2002). „The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs”. J. Biol. Chem. (United States) 277 (18): 15221-4. DOI:10.1074/jbc.C200112200. ISSN 0021-9258. PMID 11891216.
↑ Torres, G E; Yao W D, Mohn A R, Quan H, Kim K M, Levey A I, Staudinger J, Caron M G (April 2001). „Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1”. Neuron (United States) 30 (1): 121-34. DOI:10.1016/S0896-6273(01)00267-7. ISSN 0896-6273. PMID 11343649.
↑ ^10,0 ^10,1 Hirbec, Hélène; Francis Joanna C, Lauri Sari E, Braithwaite Steven P, Coussen Françoise, Mulle Christophe, Dev Kumlesh K, Coutinho Victoria, Meyer Guido, Isaac John T R, Collingridge Graham L, Henley Jeremy M, Couthino Victoria (February 2003). „Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP”. Neuron (United States) 37 (4): 625-38. DOI:10.1016/S0896-6273(02)01191-1. ISSN 0896-6273. PMID 12597860.

Literatura

Collingridge GL, Isaac JT (2003). „Functional roles of protein interactions with AMPA and kainate receptors”. Neurosci. Res. 47 (1): 3-15. DOI:10.1016/S0168-0102(03)00160-3. PMID 12941441.
Xu J, Xia J (2006). „Structure and function of PICK1”. Neurosignals 15 (4): 190-201. DOI:10.1159/000098482. PMID 17215589.
Staudinger J, Zhou J, Burgess R i dr.. (1995). „PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system”. J. Cell Biol. 128 (3): 263-71. DOI:10.1083/jcb.128.3.263. PMC 2120344. PMID 7844141.
Staudinger J, Lu J, Olson EN (1998). „Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha”. J. Biol. Chem. 272 (51): 32019-24. DOI:10.1074/jbc.272.51.32019. PMID 9405395.
Xia J, Zhang X, Staudinger J, Huganir RL (1999). „Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1”. Neuron 22 (1): 179-87. DOI:10.1016/S0896-6273(00)80689-3. PMID 10027300.
Torres R, Firestein BL, Dong H i dr.. (1999). „PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands”. Neuron 21 (6): 1453-63. DOI:10.1016/S0896-6273(00)80663-7. PMID 9883737.
Takeya R, Takeshige K, Sumimoto H (2000). „Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors”. Biochem. Biophys. Res. Commun. 267 (1): 149-55. DOI:10.1006/bbrc.1999.1932. PMID 10623590.
Cowan CA, Yokoyama N, Bianchi LM i dr.. (2000). „EphB2 guides axons at the midline and is necessary for normal vestibular function”. Neuron 26 (2): 417-30. DOI:10.1016/S0896-6273(00)81174-5. PMID 10839360.
Dev KK, Nakajima Y, Kitano J i dr.. (2001). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. 20 (19): 7252-7. PMID 11007882.
Lin WJ, Chang YF, Wang WL, Huang CY (2001). „Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1”. Biochem. J. 354 (Pt 3): 635-43. DOI:10.1042/0264-6021:3540635. PMC 1221695. PMID 11237868.
Jaulin-Bastard F, Saito H, Le Bivic A i dr.. (2001). „The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins”. J. Biol. Chem. 276 (18): 15256-63. DOI:10.1074/jbc.M010032200. PMID 11278603.
Torres GE, Yao WD, Mohn AR i dr.. (2001). „Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1”. Neuron 30 (1): 121-34. DOI:10.1016/S0896-6273(01)00267-7. PMID 11343649.
Lin SH, Arai AC, Wang Z i dr.. (2001). „The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering”. Mol. Pharmacol. 60 (5): 916-23. PMID 11641419.
Duggan A, Garcia-Anoveros J, Corey DP (2002). „The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons”. J. Biol. Chem. 277 (7): 5203-8. DOI:10.1074/jbc.M104748200. PMID 11739374.
Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). „Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)”. Biochem. J. 361 (Pt 3): 443-50. DOI:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
Hirbec H, Perestenko O, Nishimune A i dr.. (2002). „The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs”. J. Biol. Chem. 277 (18): 15221-4. DOI:10.1074/jbc.C200112200. PMID 11891216.
Perroy J, El Far O, Bertaso F i dr.. (2002). „PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7”. EMBO J. 21 (12): 2990-9. DOI:10.1093/emboj/cdf313. PMC 126066. PMID 12065412.
Jansen A, Nässel D, Madsen K i dr.. (2009). „PICK1 expression in the Drosophila nervous system primarily occurs in the nervous system”. J. Comp. Neurol. 517 (3): 313-322. DOI:10.1002/cne.22155. PMID 19757495.