QRFP

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RF (Arg-Phe) amidni peptid sa 26 aminokiselina
Identifikatori
SimboliP518; 26RFa; MGC119794; QRFP
Vanjski IDOMIM: 609795 MGI: 3630329 HomoloGene: 52341 GeneCards: P518 Gene
Ontologija gena
Molekularna funkcija • aktivnost neuropeptidnog hormona
Celularna komponenta • celularna_komponenta
Biološki proces • neuropeptidni signalni put
Ortolozi
VrstaČovekMiš
Entrez347148227717
EnsemblENSG00000188710ENSMUSG00000043102
UniProtP83859Q52KM7
RefSeq (mRNA)NM_198180NM_183424
RefSeq (protein)NP_937823NP_906269
Lokacija (UCSC)Chr 9:
132.76 - 132.76 Mb		Chr 2:
31.63 - 31.63 Mb
PubMed pretraga[1][2]

QRFP, ili RF (Arg-Phe) amidni peptid sa 26 aminokiselina, je ljudski protein. On je takođe poznat kao P518.[1]

P518 funkcioniše kao ligand visokog-afiniteta GPR103 receptora. iRNK prekursori GPR103 i P518 proteina su visoko izraženi u mozgu.[2] QRFP peptid sa 43 aminokiselina, što je duži oblik P518 peptida, je neophodan za punu agonističku aktivnosti GPR103 receptora. Intravenozna administracija QRFP peptida uzrokuje oslobađanje aldosterona, iz čega proizilazi da QRFP i GPR103 regulišu adrenalnu funkciju.[3]

Reference

  1. ↑ „Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide”. 
  2. ↑ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). „Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155”. J. Biol. Chem. 278 (30): 27652–7. DOI:10.1074/jbc.M302945200. PMID 12714592. 
  3. ↑ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). „A new peptidic ligand and its receptor regulating adrenal function in rats”. J. Biol. Chem. 278 (47): 46387–95. DOI:10.1074/jbc.M305270200. PMID 12960173. 

Literatura

  • Bruzzone F, Lectez B, Tollemer H, et al. (2007). „Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord.”. J. Neurochem. 99 (2): 616–27. DOI:10.1111/j.1471-4159.2006.04090.x. PMID 16899066. 
  • Chartrel N, Bruzzone F, Dujardin C, et al. (2006). „Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals.”. Ann. N. Y. Acad. Sci. 1040: 80–3. DOI:10.1196/annals.1327.009. PMID 15891009. 
  • Thuau R, Guilhaudis L, Ségalas-Milazzo I, et al. (2005). „Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity.”. Peptides 26 (5): 779–89. DOI:10.1016/j.peptides.2005.01.006. PMID 15808908. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Chartrel N, Dujardin C, Anouar Y, et al. (2004). „Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.”. Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15247–52. DOI:10.1073/pnas.2434676100. PMC 299975. PMID 14657341. 
  • Fukusumi S, Yoshida H, Fujii R, et al. (2004). „A new peptidic ligand and its receptor regulating adrenal function in rats.”. J. Biol. Chem. 278 (47): 46387–95. DOI:10.1074/jbc.M305270200. PMID 12960173. 
  • Jiang Y, Luo L, Gustafson EL, et al. (2003). „Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.”. J. Biol. Chem. 278 (30): 27652–7. DOI:10.1074/jbc.M302945200. PMID 12714592. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

Spoljašnje veze

  • „Peptide P518 Receptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.