| PITX2 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 2L7F, 2L7M, 2LKX | | |
| Ідентифікатори |
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| Символи | PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4 |
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| Зовнішні ІД | OMIM: 601542 MGI: 109340 HomoloGene: 55454 GeneCards: PITX2 |
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| Пов'язані генетичні захворювання |
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| Axenfeld-Rieger syndrome type 1, iridogoniodysgenesis syndrome, ring dermoid of cornea, Rieger anomaly[1] |
| Онтологія гена |
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| Молекулярна функція | • identical protein binding
• protein homodimerization activity
• GO:0000975 transcription cis-regulatory region binding
• sequence-specific DNA binding
• DNA binding
• GO:0001105 transcription coactivator activity
• chromatin DNA binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0001948, GO:0016582 protein binding
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• chromatin binding
• ribonucleoprotein complex binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• transcription factor binding
• phosphoprotein binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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| Клітинна компонента | • клітинне ядро
• цитоплазма
• transcription regulator complex
• нуклеоплазма
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| Біологічний процес | • response to vitamin A
• female gonad development
• vascular associated smooth muscle cell differentiation
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• skeletal muscle tissue development
• cell proliferation involved in outflow tract morphogenesis
• prolactin secreting cell differentiation
• in utero embryonic development
• pituitary gland development
• васкулогенез
• regulation of cell population proliferation
• myoblast fusion
• hair cell differentiation
• spleen development
• GO:0009373 regulation of transcription, DNA-templated
• transcription by RNA polymerase II
• embryonic camera-type eye development
• ventricular septum morphogenesis
• endodermal digestive tract morphogenesis
• determination of left/right symmetry
• cardiac muscle tissue development
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• subthalamic nucleus development
• ventricular cardiac muscle cell development
• left/right axis specification
• hypothalamus cell migration
• animal organ morphogenesis
• regulation of cell migration
• heart development
• embryonic digestive tract morphogenesis
• branching involved in blood vessel morphogenesis
• cardiac muscle cell differentiation
• digestive system development
• multicellular organism development
• atrioventricular valve development
• pulmonary vein morphogenesis
• cardiac neural crest cell migration involved in outflow tract morphogenesis
• embryonic hindlimb morphogenesis
• lung development
• superior vena cava morphogenesis
• positive regulation of DNA binding
• extraocular skeletal muscle development
• pulmonary myocardium development
• deltoid tuberosity development
• atrial cardiac muscle tissue morphogenesis
• male gonad development
• anatomical structure morphogenesis
• brain development
• neuron differentiation
• odontogenesis of dentin-containing tooth
• Wnt signaling pathway
• left lung morphogenesis
• somatotropin secreting cell differentiation
• positive regulation of myoblast proliferation
• camera-type eye development
• response to hormone
• odontogenesis
• iris morphogenesis
• neuron migration
• GO:1901227 negative regulation of transcription by RNA polymerase II
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | NM_000325
NM_001204397
NM_001204398
NM_001204399
NM_153426
| | NM_153427 |
| | NM_001042502
NM_001042504
NM_001286942
NM_001287048
NM_011098 |
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| RefSeq (білок) | NP_000316
NP_001191326
NP_001191327
NP_001191328
NP_700475
| | NP_700476 |
| | NP_001035967
NP_001035969
NP_001273871
NP_001273977
NP_035228 |
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| Локус (UCSC) | Хр. 4: 110.62 – 110.64 Mb | Хр. 3: 128.99 – 129.01 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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