Protein-coding gene in the species Homo sapiens
| KCNK17 |
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| Identifiers |
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| Aliases | KCNK17, K2p17.1, TALK-2, TALK2, TASK-4, TASK4, potassium two pore domain channel subfamily K member 17 |
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| External IDs | OMIM: 607370; HomoloGene: 88928; GeneCards: KCNK17; OMA:KCNK17 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 6 (human)[1] |
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| | Band | 6p21.2 | Start | 39,299,001 bp[1] |
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| End | 39,314,461 bp[1] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - ascending aorta
- right coronary artery
- islet of Langerhans
- left coronary artery
- right lung
- upper lobe of lung
- upper lobe of left lung
- lower lobe of lung
- tibia
- right atrium
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| | | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - voltage-gated ion channel activity
- potassium channel activity
- potassium ion leak channel activity
| | Cellular component | - integral component of membrane
- plasma membrane
- membrane
- integral component of plasma membrane
| | Biological process | - potassium ion transport
- regulation of ion transmembrane transport
- ion transport
- potassium ion transmembrane transport
- stabilization of membrane potential
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 6: 39.3 – 39.31 Mb | n/a |
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| PubMed search | [2] | n/a |
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| Wikidata |
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Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene.[3][4]
This gene encodes K2P17.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel, primarily expressed in the pancreas, is activated at alkaline pH.[4]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000124780 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
- ^ a b "Entrez Gene: KCNK17 potassium channel, subfamily K, member 17".
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
- Decher N, Maier M, Dittrich W, et al. (2001). "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family". FEBS Lett. 492 (1–2): 84–9. doi:10.1016/S0014-5793(01)02222-0. PMID 11248242. S2CID 23620127.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
