KCNS3

Protein-coding gene in the species Homo sapiens

KCNS3

Identifiers

Aliases

KCNS3, KV9.3, potassium voltage-gated channel modifier subfamily S member 3

External IDs

OMIM: 603888 MGI: 1098804 HomoloGene: 20518 GeneCards: KCNS3

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p24.2	Start	17,877,847 bp^[1]
Band	2p24.2	End	18,361,616 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12 A1.1\|12 5.58 cM	Start	11,140,203 bp^[2]
Band	12 A1.1\|12 5.58 cM	End	11,201,057 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

vastus lateralis muscle

visceral pleura

retinal pigment epithelium

hair follicle

palpebral conjunctiva

gastrocnemius muscle

upper lobe of left lung

pancreatic ductal cell

right lung

triceps brachii muscle

Top expressed in

morula

olfactory epithelium

white adipose tissue

superior frontal gyrus

yolk sac

esophagus

stomach

cerebellar cortex

anterior horn of spinal cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity ion channel activity potassium channel regulator activity voltage-gated potassium channel activity
Cellular component	integral component of membrane Golgi apparatus membrane voltage-gated potassium channel complex plasma membrane cytosol
Biological process	regulation of insulin secretion regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport protein homooligomerization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3790


238076

Ensembl


ENSG00000170745


ENSMUSG00000043673

UniProt


Q9BQ31


Q8BQZ8

RefSeq (mRNA)


NM_001282428 NM_002252


NM_001168564 NM_173417

RefSeq (protein)


NP_001269357 NP_002243


NP_001162036 NP_775593

Location (UCSC)

Chr 2: 17.88 – 18.36 Mb

Chr 12: 11.14 – 11.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily S member 3 (Kv9.3) is a protein that in humans is encoded by the KCNS3 gene.^[5]^[6]^[7] KCNS3 gene belongs to the S subfamily of the potassium channel family.^[7] It is highly expressed in pulmonary artery myocytes,^[8]^[9]^[10] placenta,^[11] and parvalbumin-containing GABA neurons in brain cortex.^[12]^[13] In humans, single-nucleotide polymorphisms of the KCNS3 gene are associated with airway hyperresponsiveness,^[14] whereas decreased KCNS3 mRNA expression is found in the prefrontal cortex of patients with schizophrenia.^[13]

Function

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The Kv9.3 protein (encoded by KCNS3 gene) is not functional by itself^[9] but can form functional heteromultimers with Kv2.1 (encoded by KCNB1) and Kv2.2 (encoded by KCNB2) (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins.^[8] Heteromeric Kv2.1/Kv9.3 channels form with fixed stoichiometry consisting of three Kv2.1 subunits and one Kv9.3 subunit.^[15]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170745 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043673 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shepard AR, Rae JL (September 1999). "Electrically silent potassium channel subunits from human lens epithelium". The American Journal of Physiology. 277 (3): C412–C424. doi:10.1152/ajpcell.1999.277.3.C412. PMID 10484328.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b "Entrez Gene: KCNS3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3". Retrieved 19 June 2017.
^ ^a ^b Patel AJ, Lazdunski M, Honoré E (November 1997). "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes". The EMBO Journal. 16 (22): 6615–6625. doi:10.1093/emboj/16.22.6615. PMC 1170266. PMID 9362476.
^ ^a ^b Stocker M, Kerschensteiner D (July 1998). "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain". Biochemical and Biophysical Research Communications. 248 (3): 927–934. doi:10.1006/bbrc.1998.9072. PMID 9704029.
^ Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, et al. (November 2006). "Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (5): L993-1004. doi:10.1152/ajplung.00191.2005. PMID 16815889.
^ Fyfe GK, Panicker S, Jones RL, Wareing M (October 2012). "Expression of an electrically silent voltage-gated potassium channel in the human placenta". Journal of Obstetrics and Gynaecology. 32 (7): 624–629. doi:10.3109/01443615.2012.709288. PMID 22943705. S2CID 27217929.
^ Georgiev D, González-Burgos G, Kikuchi M, Minabe Y, Lewis DA, Hashimoto T (2012). "Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex". PLOS ONE. 7 (8): e43904. Bibcode:2012PLoSO...743904G. doi:10.1371/journal.pone.0043904. PMC 3427167. PMID 22937123.
^ ^a ^b Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, et al. (January 2014). "Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia". The American Journal of Psychiatry. 171 (1): 62–71. doi:10.1176/appi.ajp.2013.13040468. PMC 3947279. PMID 24170294.
^ Hao K, Niu T, Xu X, Fang Z, Xu X (April 2005). "Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness". Human Genetics. 116 (5): 378–383. doi:10.1007/s00439-005-1256-5. PMID 15714333. S2CID 20997775.
^ Kerschensteiner D, Soto F, Stocker M (April 2005). "Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits". Proceedings of the National Academy of Sciences of the United States of America. 102 (17): 6160–6165. Bibcode:2005PNAS..102.6160K. doi:10.1073/pnas.0500468102. PMC 1087924. PMID 15827117.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin