ELK4
Protein-coding gene in the species Homo sapiens
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| Aliases | ELK4, SAP1, ETS transcription factor, ETS transcription factor ELK4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 600246; MGI: 102853; HomoloGene: 1492; GeneCards: ELK4; OMA:ELK4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[5][6][7]
Function
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[7]
Interactions
ELK4 has been shown to interact with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000158711 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026436 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
- ^ Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B (Mar 1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics. 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773.
- ^ a b "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)".
- ^ Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN (Mar 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene. 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.
- ^ Hassler M, Richmond TJ (Jun 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.
- ^ Zhu C, Johansen FE, Prywes R (Sep 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. doi:10.1128/MCB.17.9.4957. PMC 232347. PMID 9271374.
Further reading
- Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133.
- Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci. 23 (6): 213–6. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975.
- Dalton S, Treisman R (1992). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element". Cell. 68 (3): 597–612. doi:10.1016/0092-8674(92)90194-H. PMID 1339307. S2CID 26274460.
- Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)". EMBO J. 14 (11): 2589–601. doi:10.1002/j.1460-2075.1995.tb07257.x. PMC 398373. PMID 7540136.
- Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Dalton S, Treisman R (1994). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element" (PDF). Cell. 76 (2): 411. PMID 8293474. Archived from the original (PDF) on 2011-09-28. Retrieved 2011-06-29.
- Janknecht R, Hunter T (1997). "Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase". J. Biol. Chem. 272 (7): 4219–24. doi:10.1074/jbc.272.7.4219. PMID 9020136.
- Janknecht R, Hunter T (1997). "Convergence of MAP kinase pathways on the ternary complex factor Sap-1a". EMBO J. 16 (7): 1620–7. doi:10.1093/emboj/16.7.1620. PMC 1169766. PMID 9130707.
- Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS (1997). "p38-2, a novel mitogen-activated protein kinase with distinct properties". J. Biol. Chem. 272 (31): 19509–17. doi:10.1074/jbc.272.31.19509. PMID 9235954.
- Mo Y, Vaessen B, Johnston K, Marmorstein R (1998). "Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins". Mol. Cell. 2 (2): 201–12. doi:10.1016/S1097-2765(00)80130-6. PMID 9734357.
- Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 (4): 968–76. doi:10.1093/emboj/18.4.968. PMC 1171189. PMID 10022839.
- Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus". J. Biol. Chem. 274 (37): 26563–71. doi:10.1074/jbc.274.37.26563. PMID 10473620.
- Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN (2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene. 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.
- Hassler M, Richmond TJ (2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.
- Mo Y, Ho W, Johnston K, Marmorstein R (2002). "Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex". J. Mol. Biol. 314 (3): 495–506. doi:10.1006/jmbi.2001.5138. PMID 11846562.
External links
- ELK4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook ELK4
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PDB gallery
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1bc7: SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX -
1bc8: STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS -
1hbx: TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA -
1k6o: Crystal Structure of a Ternary SAP-1/SRF/c-fos SRE DNA Complex
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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