PHF10

Protein-coding gene
PHF10
Identifiers
AliasesPHF10, BAF45A, XAP135, PHD finger protein 10, SMARCG4
External IDsOMIM: 613069; MGI: 1919307; HomoloGene: 10112; GeneCards: PHF10; OMA:PHF10 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PHF10
Genomic location for PHF10
Band6q27Start169,703,902 bp[1]
End169,725,566 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for PHF10
Genomic location for PHF10
Band17|17 A2Start15,165,271 bp[2]
End15,181,535 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • right lung

  • body of pancreas

  • right coronary artery

  • tibial nerve

  • right uterine tube

  • minor salivary glands

  • ganglionic eminence

  • canal of the cervix

  • ascending aorta
Top expressed in
  • calvaria

  • spermatocyte

  • seminiferous tubule

  • abdominal wall

  • vas deferens

  • primitive streak

  • interventricular septum

  • somite

  • endocardial cushion

  • thymus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • histone acetyltransferase activity
  • histone binding
Cellular component
  • nucleus
  • npBAF complex
  • histone acetyltransferase complex
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • nervous system development
  • histone acetylation
  • negative regulation of transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55274

72057

Ensembl

ENSG00000130024

ENSMUSG00000023883

UniProt

Q8WUB8

Q9D8M7

RefSeq (mRNA)

NM_133325
NM_018288

NM_024250
NM_001360983

RefSeq (protein)

NP_060758
NP_579866

NP_077212
NP_001347912

Location (UCSC)Chr 6: 169.7 – 169.73 MbChr 17: 15.17 – 15.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 10 is a protein that in humans is encoded by the PHF10 gene.[5][6]

Function

This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130024 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023883 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aradhya S, Woffendin H, Bonnen P, Heiss NS, Yamagata T, Esposito T, Bardaro T, Poustka A, D'Urso M, Kenwrick S, Nelson DL (January 2002). "Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28". Genomics. 79 (1): 31–40. doi:10.1006/geno.2001.6680. PMID 11827455.
  6. ^ a b "Entrez Gene: PHF10 PHD finger protein 10".

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Rogner UC, Heiss NS, Kioschis P, Wiemann S, Korn B, Poustka A (October 1996). "Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28". Genome Research. 6 (10): 922–34. doi:10.1101/gr.6.10.922. PMID 8908511.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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