HOXB7

Protein-coding gene in humans
HOXB7
Identifiers
AliasesHOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDsOMIM: 142962; MGI: 96188; HomoloGene: 55828; GeneCards: HOXB7; OMA:HOXB7 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HOXB7
Genomic location for HOXB7
Band17q21.32Start48,607,232 bp[1]
End48,633,572 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for HOXB7
Genomic location for HOXB7
Band11 D|11 59.82 cMStart96,177,449 bp[2]
End96,180,988 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • caput epididymis

  • seminal vesicula

  • renal medulla

  • endometrium

  • glomerulus

  • metanephric glomerulus

  • kidney tubule

  • kidney

  • rectum
Top expressed in
  • Hindgut

  • neural tube

  • intestinal villus

  • proximal tubule

  • allantois

  • yolk sac

  • sclerotome

  • adrenal gland

  • axial skeleton

  • kidney
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • protein binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
  • nuclear body
Biological process
  • multicellular organism development
  • embryonic skeletal system morphogenesis
  • myeloid cell differentiation
  • positive regulation of branching involved in ureteric bud morphogenesis
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • anterior/posterior pattern specification
  • transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3217

15415

Ensembl

ENSG00000260027

ENSMUSG00000038721

UniProt

P09629

P09024

RefSeq (mRNA)

NM_004502

NM_010460

RefSeq (protein)

NP_004493

NP_034590

Location (UCSC)Chr 17: 48.61 – 48.63 MbChr 11: 96.18 – 96.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[5][6]

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[7]

Interactions

HOXB7 has been shown to interact with PBX1[8] and CREB-binding protein.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000260027 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038721 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. ^ "Entrez Gene: HOXB7 homeobox B7".
  8. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi:10.1101/gad.9.6.663. PMID 7729685.
  9. ^ Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene. 18 (27): 4007–4014. doi:10.1038/sj.onc.1202776. PMID 10435624.

Further reading

  • Baier LJ, Hannibal MC, Hanley EW, Nabel GJ (1991). "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood. 78 (4): 1047–1055. doi:10.1182/blood.V78.4.1047.1047. PMID 1678287.
  • Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–69. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
  • Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–197. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
  • Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–8540. Bibcode:1989PNAS...86.8536S. doi:10.1073/pnas.86.21.8536. PMC 298317. PMID 2573064.
  • Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–10402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
  • Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". Genome. 31 (2): 745–756. doi:10.1139/g89-133. PMID 2576652.
  • Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–4918. Bibcode:1987PNAS...84.4914S. doi:10.1073/pnas.84.14.4914. PMC 305217. PMID 2885844.
  • Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC (1995). "The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation". Blood. 85 (3): 692–697. doi:10.1182/blood.V85.3.692.bloodjournal853692. PMID 7530503.
  • Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi:10.1101/gad.9.6.663. PMID 7729685.
  • Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G (1995). "Nucleolar localisation of three Hox homeoproteins". J. Cell Sci. 108 (1): 187–193. doi:10.1242/jcs.108.1.187. PMID 7738096.
  • Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H (1993). "Identification of homeobox genes expressed in human T-lymphocytes". Biochem. Biophys. Res. Commun. 196 (1): 203–208. doi:10.1006/bbrc.1993.2235. PMID 8105782.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–905. Bibcode:1996PNAS...93..900M. doi:10.1073/pnas.93.2.900. PMC 40155. PMID 8570656.
  • Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–115. doi:10.1159/000134320. PMID 8646877.
  • Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP (1996). "HOXB7 constitutively activates basic fibroblast growth factor in melanomas". Mol. Cell. Biol. 16 (9): 4842–4851. doi:10.1128/mcb.16.9.4842. PMC 231486. PMID 8756643.
  • LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene. 15 (17): 2059–2067. doi:10.1038/sj.onc.1201367. PMID 9366523.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–115. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e
  • 1ahd: DETERMINATION OF THE NMR SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
    1ahd: DETERMINATION OF THE NMR SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
  • 1hom: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
    1hom: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
  • 1san: THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN
    1san: THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN
  • 2hoa: STRUCTURE DETERMINATION OF THE ANTP(C39->S) HOMEODOMAIN FROM NUCLEAR MAGNETIC RESONANCE DATA IN SOLUTION USING A NOVEL STRATEGY FOR THE STRUCTURE CALCULATION WITH THE PROGRAMS DIANA, CALIBA, HABAS AND GLOMSA
    2hoa: STRUCTURE DETERMINATION OF THE ANTP(C39->S) HOMEODOMAIN FROM NUCLEAR MAGNETIC RESONANCE DATA IN SOLUTION USING A NOVEL STRATEGY FOR THE STRUCTURE CALCULATION WITH THE PROGRAMS DIANA, CALIBA, HABAS AND GLOMSA
  • 9ant: ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
    9ant: ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
Stub icon

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e