OLIG1

Protein-coding gene in the species Homo sapiens
OLIG1
Identifiers
AliasesOLIG1, BHLHB6, BHLHE21, oligodendrocyte transcription factor 1
External IDsOMIM: 606385; MGI: 1355334; HomoloGene: 9667; GeneCards: OLIG1; OMA:OLIG1 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for OLIG1
Genomic location for OLIG1
Band21q22.11Start33,070,141 bp[1]
End33,072,413 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for OLIG1
Genomic location for OLIG1
Band16|16 C3.3Start91,066,660 bp[2]
End91,068,821 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • inferior ganglion of vagus nerve

  • external globus pallidus

  • subthalamic nucleus

  • ventral tegmental area

  • substantia nigra

  • medulla oblongata

  • amygdala

  • superior vestibular nucleus

  • putamen

  • hypothalamus
Top expressed in
  • optic nerve

  • substantia nigra

  • spinal cord

  • globus pallidus

  • anterior horn of spinal cord

  • ventral tegmental area

  • lateral geniculate nucleus

  • dorsal tegmental nucleus

  • suprachiasmatic nucleus

  • superior colliculus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • protein dimerization activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • multicellular organism development
  • neuron fate commitment
  • oligodendrocyte differentiation
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116448

50914

Ensembl

ENSG00000184221

ENSMUSG00000046160

UniProt

Q8TAK6

Q9JKN5

RefSeq (mRNA)

NM_138983

NM_016968

RefSeq (protein)

NP_620450

NP_058664

Location (UCSC)Chr 21: 33.07 – 33.07 MbChr 16: 91.07 – 91.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184221 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046160 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM (Sep 2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (19): 10851–6. Bibcode:2001PNAS...9810851L. doi:10.1073/pnas.181340798. PMC 58563. PMID 11526205.
  6. ^ "Entrez Gene: OLIG1 oligodendrocyte transcription factor 1".

Further reading

  • Zhou Q, Wang S, Anderson DJ (Feb 2000). "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors". Neuron. 25 (2): 331–43. doi:10.1016/S0896-6273(00)80898-3. PMID 10719889. S2CID 16560063.
  • Takebayashi H, Yoshida S, Sugimori M, Kosako H, Kominami R, Nakafuku M, Nabeshima Y (Dec 2000). "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3". Mechanisms of Development. 99 (1–2): 143–8. doi:10.1016/S0925-4773(00)00466-4. PMID 11091082. S2CID 1472243.
  • McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening". Gene Expression Patterns. 2 (3–4): 329–35. doi:10.1016/S0925-4773(02)00390-8. PMID 12617822.
  • McLellan AS, Langlands K, Kealey T (Dec 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening". Mechanisms of Development. 119 (Suppl 1): S285-91. doi:10.1016/S0925-4773(03)00130-8. PMID 14516699. S2CID 5903576.
  • Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD (Dec 2004). "bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS". Science. 306 (5704): 2111–5. Bibcode:2004Sci...306.2111A. doi:10.1126/science.1103709. PMID 15604411. S2CID 31228720.
  • Jakovcevski I, Zecevic N (Nov 2005). "Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS". The Journal of Neuroscience. 25 (44): 10064–73. doi:10.1523/JNEUROSCI.2324-05.2005. PMC 6725798. PMID 16267213.
  • Goris A, Yeo TW, Maranian M, Walton A, Ban M, Gray J, Compston A, Sawcer S (Nov 2006). "Novel Olig 1-coding variants and susceptibility to multiple sclerosis". Journal of Neurology, Neurosurgery, and Psychiatry. 77 (11): 1296–7. doi:10.1136/jnnp.2006.090639. PMC 2077377. PMID 16820418.
  • Ruf N, Martelli M, Weschke B, Uhlenberg B (Apr 2007). "Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy". American Journal of Medical Genetics Part B. 144B (3): 365–6. doi:10.1002/ajmg.b.30434. PMID 17171653. S2CID 25663863.
  • Brena RM, Morrison C, Liyanarachchi S, Jarjoura D, Davuluri RV, Otterson GA, Reisman D, Glaros S, Rush LJ, Plass C (Mar 2007). "Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer". PLOS Medicine. 4 (3): e108. doi:10.1371/journal.pmed.0040108. PMC 1831740. PMID 17388669.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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